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Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal.

Cardoso TA, Coan AC, Kobayashi E, Guerreiro CA, Li LM, Cendes F

Department of Neurology, FCM, State University of Campinas-UNICAMP, Brazil.

The authors performed hippocampal volumetry and T2 relaxometry in 84 consecutive patients with partial epilepsy from a protocol for antiepileptic drug (AED) withdrawal after at least 2 years of seizure control. Seizure recurrence after AED withdrawal was more frequent among patients with hippocampal atrophy and abnormal hippocampal T2 signal.

Published 11 July 2006 in Neurology, 67(1): 134-6.
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